DANOFLOXANCIN MESYLATE
Danofloxacin mesylate
CAS: 119478-55-6
Molecular Formula: C20H24FN3O6S
DANOFLOXANCIN MESYLATE - Names and Identifiers
| Name | Danofloxacin mesylate |
| Synonyms | Advoci Nofloxacin CP-76136-27 DANOFLOXACIN MESILATE Danofloxacin mesylate DANOFLOXACIN MESYLATE DANOFLOXACIN MESULATE DANOFLOXANCIN MESYLATE Mesylate Dan Nuosha star 1-cyclopropyl-6-fluoro-7-[(1s,4s)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid monomethanesulfonate |
| CAS | 119478-55-6 |
| EINECS | 638-813-3 |
| InChI | InChI=1/C19H20FN3O3.CH4O3S/c1-21-7-12-4-11(21)8-22(12)17-6-16-13(5-15(17)20)18(24)14(19(25)26)9-23(16)10-2-3-10;1-5(2,3)4/h5-6,9-12H,2-4,7-8H2,1H3,(H,25,26);1H3,(H,2,3,4)/t11-,12-;/m0./s1 |
DANOFLOXANCIN MESYLATE - Physico-chemical Properties
| Molecular Formula | C20H24FN3O6S |
| Molar Mass | 453.48 |
| Melting Point | 337-339°C |
| Boling Point | 569.3°C at 760 mmHg |
| Flash Point | 298.1°C |
| Solubility | It is soluble in water, slightly soluble in methanol, almost insoluble in chloroform, and has no volatile pungent odor. Solubility in water (25 ℃):10%(g/ml),PH value 3.5~4.5, the color of the aqueous solution is colorless or yellowish green. |
| Vapor Presure | 8.41E-14mmHg at 25°C |
| Appearance | Crystalline solid |
| Color | White to Off-White |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| Stability | Hygroscopic |
| MDL | MFCD00673687 |
| Physical and Chemical Properties | Storage Conditions: 0-6 ℃ |
| In vitro study | Danofloxacin is a fluoroquinolone synthetic antibacterial agent that acts primarily by inhibiting bacterial DNA gyrase, which is necessary for DNA supercoiling to provide proper DNA spatial arrangement in bacterial cells. The minimum inhibitory concentration of Danofloxacin, against 90%(MIC90) contemporary Pasteurella haemolytica , Pasteurella multocida and Haemophilus somnus, the most important respiratory pathogens of domestic animals in Europe and North America, is 0.125 μg/ml. |
| In vivo study | In the in vivo rat protection assay, the median protective dose (PD50) of Danofloxacin for P. multocida, E. coli and S. Chocolate UIs was 0.38,0.8, and 2.42 mg/kg, respectively. |
DANOFLOXANCIN MESYLATE - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29339900 |
DANOFLOXANCIN MESYLATE - Reference
| Reference Show more | 1. [IF=1.786] Xia Xiao et al."Comparative pharmacokinetics of danofloxacin in healthy and Pasteurella multocida infected ducks."J Vet Pharmacol Ther. 2018 Dec;41(6):912-918 2. [IF=1.786] Xia Xiao et al."Comparative pharmacokinetics of danofloxacin in healthy and Pasteurella multocida infected ducks."J Vet Pharmacol Ther. 2018 Dec;41(6):912-918 |
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View History
DANOFLOXANCIN MESYLATE
3-ButenylMagnesiuM broMide, 1.0 M solution in THF, SpcSeal
2-氨基苯并噻唑-6-甲酸
diterbium tritungsten dodecaoxide
METHYL 5-(4-FLUOROPHENYL)ISOXAZOLE-3-CARBOXYLATE
戊烯二醛二苯胺.盐酸盐, 异构体混合物
5-CHLORO-1-[3-(TRIFLUOROMETHYL)BENZYL]-1H-INDOLE-2,3-DIONE 3-(N-[2,6-DICHLORO-4-(TRIFLUOROMETHYL)PHENYL]HYDRAZONE)
NAPHTHOL AS-BI BETA-D-GLUCURONIDE
PNP BETA-D-GALACTOPYRANOSIDE
[[4-(DIETHYLSULFAMOYL)-O-TOLYL]OXY]-ACETIC ACID
3-ButenylMagnesiuM broMide, 1.0 M solution in THF, SpcSeal
2-氨基苯并噻唑-6-甲酸
diterbium tritungsten dodecaoxide
METHYL 5-(4-FLUOROPHENYL)ISOXAZOLE-3-CARBOXYLATE
戊烯二醛二苯胺.盐酸盐, 异构体混合物
5-CHLORO-1-[3-(TRIFLUOROMETHYL)BENZYL]-1H-INDOLE-2,3-DIONE 3-(N-[2,6-DICHLORO-4-(TRIFLUOROMETHYL)PHENYL]HYDRAZONE)
NAPHTHOL AS-BI BETA-D-GLUCURONIDE
PNP BETA-D-GALACTOPYRANOSIDE
[[4-(DIETHYLSULFAMOYL)-O-TOLYL]OXY]-ACETIC ACID